Quetiapine (Seroquel) As An Atypical Antipsychotic
1. Pharmacology:
Dibenzothiazepine class
An antagonist with affinity binding for 5HT1A/2, D1-2, alpha1-2, and H1 receptors. No affinity for the BZD or muscarinic receptors.
2. Pharmacokinetics:
Rapidly absorbed with peak concentrations within 1.5 hours. 100% bioavailable.
PB: 83% at therapeutic dosages
Vd: 10+ 4 L/kg
T1/2: 7 hours
Major Metabolic Pathway: CYP3A4
3. Indications: Same as traditional agents:
Management of Psychotic Disorders: quetiapine's main advantage over traditional agents is that the evidence for benefit in the treatment of negative symptoms of schizophrenia. The drug has not been systematically evaluated in trials longer than 6 weeks.
Pregnancy Distinction C: No regulated concentrates on of quetiapine utilize in pregnant ladies, but beast contemplates exhibited no teratogenic impacts and some proof of embryo/fetal toxicity; no sufficient examines of quetiapine XR utilize in pregnant ladies, but some proof of embryo/fetal toxicity; both ought to just be utilized if potential hazard defends potential danger to embryo.
Lactation: Unknown if quetiapine is discharged in human drain, but is discharged in milk of tested creatures, consequently producer proposes mothers not breast food while taking the solution; quetiapine XR has been demonstrated to be discharged in human drain, consequently alert is prescribed to nurturing mothers.
4. Most Common Side Effects:
Somnolence, constipation, weight gain, orthostasis, agitation, dry mouth, increased LFT's, dizziness.
5. Dosing:
Starting dosage: 525 mg bid
Increase dosage in increments of 25-50 mg bid or tid on the second or 3 day as tolerated.
Range: 150-750 mg/day
Available: 25mg, 100mg and 200 mg tablets
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